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Alzheimer's disease

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  • 60-year-old patient presented with memory impairement. There was parietal and hippocampal (MTAS 2) volume loss. While the reduction in volume between the two scan was minimal, it was significant for such a short interval.
  • Amyloid PET was postive with loss of supratentorial grey-white differentiation.

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  • 55-year-old patient with amnestic cognitive impairment.
  • There was marked mesial and anterior temporal volume loss (MTAS 3).
  • Parietal volume loss on the left was mild.

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  • A 30-year-old patient with a family history of Alzheimer's disease presented with cognitive impairment.
  • While clearly abnormal for age, the volume loss in the parietal lobes was relatively mild. Hippocampal volume was within normal limits.
  • FDG-PET showed marked hypometabolism in the parietal and occipital lobes. The Z-scores on standarised surface projection (Minoshima) maps were between -11 and -13.

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  • A 75-year-old patient presented with memory impairment.
  • MRI showed excessive volume loss affecting the hippocampi (MTAS 2.5-3) and parietal lobes.
  • The parietal volume loss was paired with reduced CBF on ASL.