Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Case 1Case 2Case 3Case 4 A 55 year old patient with no cardiovascular risk factors presented with recurrent headache. MRI showed a confluent leukoencephalopathy, involving the external capsules and anterior temporal lobes, and lacunar infarcts. There were deep and lobar microhaemorrhages. 50 year old patient with no cardiovascular risk factors had recurrent strokes. MRI showed a severe burden of small vessel disease, multiple lacunar infarcts and mixed distribution microhaemorrhages. 50-year-old patient presented with a homonymous hemianopia and mixed sensory and motor deficits. MRI showed an acute left thalamic infarct and a diffuse leukoencephalopathy that involved the external capsules and anterior temporal lobes.