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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)

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  • A 55-year-old patient with no cardiovascular risk factors presented with recurrent headache.
  • MRI showed a confluent leukoencephalopathy, involving the external capsules and anterior temporal lobes, and lacunar infarcts.
  • There were deep and lobar microhaemorrhages.

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  • 50-year-old patient with no cardiovascular risk factors had recurrent strokes.
  • MRI showed a severe burden of small vessel disease, multiple lacunar infarcts and mixed distribution microhaemorrhages.

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  • 50-year-old patient presented with a homonymous hemianopia and mixed sensory and motor deficits.
  • MRI showed an acute left thalamic infarct and a diffuse leukoencephalopathy that involved the external capsules and anterior temporal lobes.