Cytotoxic lesion of the corpus callosum

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  • 40-year-old patient with longterm epilepsy had his anti-epileptic medication changed following an increase in seizure frequency.
  • CT showed low density in the splenium of the corpus callosum.
  • On MRI, there was T2-hyperintensity and diffusion restriction in the same region.

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  • A 50-year-old patient underwent a suboccipital decompression due to a posterior fossa haematoma.
  • The presence of deep microhaemorrhages suggested that the haemorrhage was a consequence of hypertension.
  • The symmetrical diffusion restriction within the splenium of the corpus callosum was compatible with a CLOCC.