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Huntingdon's disease

Huntingdon's disease is characterised by atrophy of the caudate nuclei resulting in a 'boxed' appearance of the frontal horns o f the lateral ventricles in the coronal plane.

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  • A 50-year-old male presented with increasing clumsiness, jerky arm movements and mood swings.
  • MRI showed relatively mild caudate head atrophy and putaminal T2-hyperintensity.

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  • 50-year-old male with increasing clumsiness and jerky arm movements.
  • MRI showed atrophy and hyperintensity of the corpora striata on both sides.
  • A 55-year-old patient with a history of depression presented after worsening incoordination.
  • Imaging showed marked atrophy of the caudate head. There was less pronounced atrophy of the T2-hyperintense putamina.