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Multisystem Atrophy - Parkinsonian Type (MSA-P)

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  • 55-year-old female with left sided parkinsonism and orthostatic systoms.

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  • 80-year-old patient presented with asymmetric parkinsonism (left > right) with freezing and early falls with poor response to levodopa.
  • MRI showed putaminal atrophy, susceptibility artefact and T2-hyperintensity along the lateral aspect of the putamina.
  • DaTscan showed markedly reduced tracer uptake in the putamina bilaterally.

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  • 60-year-old patient with a bilateral tremor.
  • T2 weighted imaging shows the lateral rim sign and mild putaminal volume loss.
  • While SWI was not performed, low signal was seen in the putamina on EPI DWI, which is sensitive to susceptibility artefact.